🪶Indigenous / Native American

Mayapple

Podophyllum peltatum

About Mayapple

Mayapple (Podophyllum peltatum) is a herb used in the Indigenous / Native American tradition to help with Constipation, Liver Support, Detox, and Parasites. The aerial parts and leaves are the parts traditionally used, taken internally.

Botanical background

Podophyllum is an herbaceous perennial plant in the family Berberidaceae, described as a genus by Linnaeus in 1753. In the past, several species were included in the genus, but all but one have been transferred to other genera (Dysosma, Pilea, and Sinopodophyllum). The one remaining species is Podophyllum peltatum, with common names mayapple, American mandrake, wild mandrake, and ground lemon. It is widespread across most of the eastern United States and southeastern Canada.

Source: Wikipedia, via iNaturalist

Parts used

Aerial Parts · internalLeaves · internal
🍵

Tea / Infusion

1–3 cups daily
  • Steep 1–2 tsp of dried Mayapple in freshly boiled water for 5–10 minutes.
  • Cover while steeping.
  • Strain and drink.
💧

Tincture

20–40 drops in water, 2–3× daily
  • Pack dried Mayapple into a jar and cover with 40–60% alcohol.
  • Seal and steep for 4–6 weeks, shaking daily.
  • Strain and store in a dark dropper bottle.
💊

Powder / Capsule

500 mg – 1 g, 1–3× daily
  • Grind dried Mayapple into a fine powder.
  • Fill size 00 capsules or stir into smoothies or honey.

Contraindications

  • Pregnancy & breastfeeding — insufficient safety data; consult your doctor
  • Children under 12 — therapeutic dosage not established
  • Active liver disease — monitor liver enzymes with long-term use

Warnings

⚠️ Pregnancy & Breastfeeding

Safety during pregnancy and breastfeeding has not been established for most herbal remedies. Consult your midwife or doctor before use.

⚠️ Liver Health

Some herbs used for liver conditions can be hepatotoxic at high doses. Have liver function monitored if using long-term.

⚠️ Allergic Reactions

Discontinue immediately if you experience rash, itching, swelling, or difficulty breathing.

⚠️ Not Medical Advice

This information is for educational purposes only. Always consult a qualified healthcare provider before using herbal remedies.

Where to find in nature

Native region

North America

Climate

Varied — temperate to subarctic

Habitat

Prairies, woodlands, wetlands, and mountain meadows of North America

🌿 To see Mayapple growing, visit botanical gardens, university plant collections, or specialist herb nurseries near you. If foraging in the wild, always work with an expert identifier — never consume a plant you are not 100% certain of.

Where to buy

In store

  • Health food stores (Whole Foods, Natural Grocers, Holland & Barrett, GNC)
  • Naturopathic clinics and integrative medicine practices
  • Specialist herbal apothecaries and herbalist practices
  • Farmers markets with herb vendors

Online

iHerb

Wide selection of standardised extracts, capsules, and powders with lab testing

Mountain Rose Herbs

Premium bulk dried herbs — certified organic, ethically sourced

Starwest Botanicals

Large selection of certified organic bulk herbs and powders

Herb Pharm

High-quality liquid extracts and tinctures, rigorous quality standards

Amazon

Convenient — verify brand certifications and check third-party testing

Etsy

Small-batch artisan herbalists, hand-harvested and wildcrafted herbs

Quality tips

When buying Mayapple, look for: certified organic labelling, clearly stated country of origin, third-party lab testing for heavy metals and pesticides, and a batch expiry date. Standardised extracts offer consistent dosing; bulk dried herbs are more economical for regular use. Avoid very cheap, unlabelled products — quality varies enormously.